We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
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Most Useful Reviews
9
Reduced sensitivity
40 people found this helpful
I’ve taken calcium supplements regularly as I avoid dairy. Though I consume green veggies and nuts, I still notice enamel sensitivity. Hydroxyapatite works just as well to strengthen my teeth and reduce sensitivity, which has improved as I’ve noted new enamel growth on defects. It’s crucial to monitor vitamin D levels for calcium absorption. Avoid breathing through your mouth, particularly at night, for better dental health.
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7.5
Supports bone metabolism
14 people found this helpful
Calcium in the form of hydroxyapatite has a positive effect on bone metabolism. It's contained in this dietary supplement in a ratio of 2:1 with phosphorus, allowing for complete absorption from the gastrointestinal tract. The slow release of calcium prevents peak hypercalcemia, aiding the fixation of calcium in bone and reducing its excretion by the kidneys. This supplement may be recommended by a health professional.
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9
Improved bone density
10 people found this helpful
Calcium Hydroxyapatite is extremely effective! My bone density has improved since I started these capsules.
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 88 Reviews
7.9
All Reviews
Positive Reviews
Negative Reviews
9
Reduced sensitivity
40 people found this helpful
I’ve taken calcium supplements regularly as I avoid dairy. Though I consume green veggies and nuts, I still notice enamel sensitivity. Hydroxyapatite works just as well to strengthen my teeth and reduce sensitivity, which has improved as I’ve noted new enamel growth on defects. It’s crucial to monitor vitamin D levels for calcium absorption. Avoid breathing through your mouth, particularly at night, for better dental health.
Read More
7.5
Supports bone metabolism
14 people found this helpful
Calcium in the form of hydroxyapatite has a positive effect on bone metabolism. It's contained in this dietary supplement in a ratio of 2:1 with phosphorus, allowing for complete absorption from the gastrointestinal tract. The slow release of calcium prevents peak hypercalcemia, aiding the fixation of calcium in bone and reducing its excretion by the kidneys. This supplement may be recommended by a health professional.
Read More
9
Improved bone density
10 people found this helpful
Calcium Hydroxyapatite is extremely effective! My bone density has improved since I started these capsules.
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7.5
Strengthened bones
10 people found this helpful
A good natural calcium for strong teeth and bones, which helped me recover quickly after a fracture.
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9
Bone density improved
8 people found this helpful
After taking this product for 12 months, I have noticed significant improvement in my bone density. They are convenient to take without any side effects, making it a great addition to my regimen.
Bone pain is a discomfort or ache that originates within the bones themselves and can range from mild to severe. It is different from muscle or joint pain, as it directly affects the skeletal structure. Bone pain can be caused by a variety of factors, including injuries, medical conditions such as osteoarthritis or osteoporosis, infections, or tumors. Symptoms may vary depending on the underlying cause but often include a dull, penetrating ache that may worsen with movement or pressure.
If you're experiencing persistent bone pain, it’s essential to consult with a healthcare professional for a proper diagnosis and treatment plan. Imaging tests like X-rays, MRI, or CT scans may be utilized to determine the root cause of the pain. Treatment can vary widely, ranging from medications to alleviate pain and inflammation to physical therapy or, in some cases, surgical interventions. Understanding the underlying cause is crucial to effectively managing bone pain and ensuring the best path to recovery.
Calcium is a chemical element represented by the symbol Ca and atomic number 20. It is an essential mineral in the body, playing a critical role in various physiological processes. As one of the most abundant elements in nature, calcium is particularly vital for maintaining strong bones and teeth, where about 99% of the body's calcium is stored. Beyond its structural function, calcium is crucial in muscle contraction, blood clotting, and nerve transmission, making it a key player in overall health.
Dietary sources of calcium include dairy products such as milk, yogurt, and cheese, as well as leafy green vegetables, nuts, seeds, and fortified foods. The recommended daily intake of calcium varies by age and sex, but generally, adults should aim for approximately 1,000 mg per day. For those who may struggle to meet their needs through diet alone, calcium supplements are available but should be taken with caution. It's essential to consult with a healthcare provider before starting any supplement regimen to avoid potential side effects or interactions with medications.
Calcium is an essential mineral that plays a critical role in maintaining bone health and strength. Adequate calcium intake is crucial for the prevention of various bone-related issues, including osteopenia and osteoporosis, conditions that can lead to increased bone pain and fractures. When the body does not receive enough calcium, it may start to leach this mineral from the bones, potentially leading to weakness and pain. Therefore, ensuring you meet your daily calcium requirements can contribute to healthier bones and may, in turn, help alleviate some types of bone pain associated with deficiencies.
However, it's essential to note that while calcium is fundamental for bone health, it may not directly relieve bone pain caused by other factors such as injury, arthritis, or other medical conditions. For those experiencing chronic bone pain, incorporating calcium-rich foods into your diet—such as dairy products, leafy greens, and fortified foods—should be part of a broader approach that includes medical evaluation and potential treatment options. Consulting a healthcare professional is advised to determine the underlying causes of bone pain and to develop a comprehensive plan that may include dietary adjustments, exercise, and medications if necessary.
Based on user reviews, results from taking calcium hydroxyapatite supplements for bone pain can vary significantly from person to person. Some users report feeling improvements in their bone health and density within a few days to weeks of initiating use. For instance, one user noticed a decrease in back pain within just three days of resuming the supplement after a break Read Review. Meanwhile, others state that significant changes, such as improved bone density, were observed after taking the supplement for several months to up to a year Read Review.
For those with conditions like osteopenia or osteoporosis, some users experienced noticeable changes after about two months of consistent use, including increases in bone mineral density as confirmed through tests Read Review. Regular monitoring, possibly in conjunction with a healthcare provider's guidance, appears essential for optimizing results from such supplements. Overall, it seems that while initial relief may come quickly for some, others may need to commit to longer-term use to achieve their health goals.
This supplement's effectiveness regarding bone pain is somewhat ambiguous based on the existing research. A study explored the effects of calcium treatment in patients experiencing bone pain associated with osteomalacia due to intravenous iron infusions. While the research observed improvements in biochemical markers and a reduction in pain scores after supportive treatment—which included calcium, phosphate, and active vitamin D supplementation—the specific contribution of calcium to alleviating bone pain could not be isolated from the other treatments utilized in the study [1].
This lack of definitive evidence means that while calcium may play a role in addressing bone pain as part of a broader treatment regime, its direct efficacy as a standalone supplement for this issue remains inconclusive. For anyone considering calcium supplementation specifically for bone pain relief, it may be advisable to consult with a healthcare provider for personalized advice and further investigation into appropriate treatment options.
Based on user reviews, it appears that many individuals have reported significant improvements in their bone health and density after incorporating calcium hydroxyapatite supplements into their daily regimen. Users have noted increases in bone mineral density as confirmed through DEXA scans, with some experiencing changes as soon as two months into use Read Review. One user specifically shared that after two years of continuous use for osteopenia, their scan showed a regrowth in bone density, which is especially noteworthy given the typical progression of that condition Read Review.
Moreover, several reviews highlight rapid personal outcomes, such as improved enamel sensitivity and stronger teeth, illustrating the compound's versatility in promoting not just bone health but also dental health Read Review. Users report feeling more resilient and less fatigued, with many expressing newfound confidence in their bone structure as they navigate life, especially after fractures or in older age Read Review. While individual results can vary significantly based on factors like diet and underlying health conditions, the consensus appears to lean toward this supplement being a beneficial addition for those looking to bolster their bone and dental health.
Users have reported that combining calcium hydroxyapatite with other supplements, particularly vitamins D and K2, enhances its effectiveness in managing bone health and pain. Several reviewers noted improvements in their bone density and overall skeletal health when taking these vitamins alongside the calcium supplement. For instance, one user shared that they experienced significant bone density gains when they included vitamin D3 and K2 in their regimen, which was also recommended by their nutritionist Read Review. Another user highlighted how their mother's osteoporosis condition markedly improved with the addition of these vitamins Read Review.
Moreover, some users suggested cycling their calcium intake to maximize bone absorption and avoid potential side effects like kidney stones. They specifically mentioned using calcium hydroxyapatite in conjunction with vitamin D and ensuring that the calcium reaches their bones effectively Read Review. This strategic approach appears to be beneficial for users looking to optimize the impact of their supplements, particularly after experiencing bone fractures or during periods of accelerated bone loss due to age or health conditions. Overall, it seems that combining these supplements can lead to improved bone health and reduced pain.
Users have reported positive experiences with calcium supplementation, particularly with calcium hydroxyapatite, indicating it’s a highly effective form for improving bone health and alleviating bone pain. Many noted that the combination of calcium with phosphorus aids absorption, which is essential for enhancing bone density and overall skeletal health. For instance, one user mentioned a significant improvement in bone density after consistently taking this supplement for 12 months Read Review. Moreover, users typically recommend maintaining a regimen that includes vitamins K2 and D3 to enhance calcium effectiveness and to mitigate potential risks, such as kidney stone formation Read Review.
Dosage variation is not directly addressed, but several users implied that maintaining a consistent intake, whether through daily capsules Read Review or cycling the supplement, yields the best results for bone pain relief and overall bone health Read Review. Furthermore, one user highlighted that their periodic use of the supplement effectively resolved bone pain associated with growth Read Review. For individuals seeking to tackle bone health issues or enhance bone density, adhering to a trusted formula of calcium hydroxyapatite appears to be well-supported through user testimonials.
9
Pain alleviated quickly
3 people found this helpful
I sought calcium with phosphorus as it's absorbed best this way. I used it during pregnancy, and when I stopped, my back started to hurt. Upon resuming after three days, the pain decreased and eventually disappeared.
9
Bone density improved
8 people found this helpful
After taking this product for 12 months, I have noticed significant improvement in my bone density. They are convenient to take without any side effects, making it a great addition to my regimen.
9
Increased density
2 people found this helpful
Effective! After taking calcium hydroxyapatite for 2 months, bioimpedancemetry indicated my bone mineral density increased by 1.5% from 2.5% to 4%. According to the doctor, this is a good outcome.
10
Gained bone density
2 people found this helpful
I'm in my mid-50s and prior to taking this calcium due to osteopenia, I was losing bone density. After two years of taking it twice daily and with exercise, my DEXA scan showed I gained bone density, which is fantastic considering I would normally lose bone. My spine has returned to normal, and while my hips still have some osteopenia, I've gained bone.
9
Reduced sensitivity
40 people found this helpful
I’ve taken calcium supplements regularly as I avoid dairy. Though I consume green veggies and nuts, I still notice enamel sensitivity. Hydroxyapatite works just as well to strengthen my teeth and reduce sensitivity, which has improved as I’ve noted new enamel growth on defects. It’s crucial to monitor vitamin D levels for calcium absorption. Avoid breathing through your mouth, particularly at night, for better dental health.
9
Accelerated healing
2 people found this helpful
Helped build my bones! I broke my foot and, due to osteopenia, the bone was slow to heal. After starting this supplement, the bone finally healed a few weeks later. I fell again but did not break any bones. I plan on taking this for life!
7.5
Quality supplement
7 people found this helpful
My bone density test has improved, which is fantastic as I had a calcium deficiency. Along with vitamins D3 & K2, it’s doing its job. My nutritionist advised this is the best quality calcium supplement, and I like it because it works and is easy to take.
9
Improved bone condition
2 people found this helpful
I found this calcium to be very effective, as I had previously taken citrate before switching. My mother has osteoporosis and, along with vitamin D and K2, this complex improved her bone condition markedly on densitometry. I highly recommend it.
9
Calcium safety
7 people found this helpful
Many fear calcium may cause an excess and stone formation. To avoid this, I consume this specific form in cycles and ensure it reaches my bones with vitamins K2 and D. I take it yearly, and I’m pleased with the results, especially for my bone health after a hip fracture.
9
Bone pain resolved
2 people found this helpful
I purchased it for my child whose bones ached due to rapid growth. The doctor recommended calcium hydroxyapatite from American sites. Bone pain issues resolved swiftly. Now, it's prescribed periodically for prevention.
8
Calcium's role in bone pain unclear
In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution.
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
References
von Brackel FN, Grambeck J, Barvencik F, Amling M, Oheim R. In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution. JBMR Plus. 2024;8:ziae139. doi:10.1093/jbmrpl/ziae139